Rie Watanabe-Fukunaga,

Neal G. Copeland*,Brannan C,Copeland N,Kenkins N, Nagata S

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Fas antigen is a cell-surface protein that mediates apoptosis. It is expressed in various tissues including the thymus and has structural homology with a number of cell-surface receptors, including tumour necrosis factor receptor and nerve growth factor receptor. Mice carrying the lymphoprolifer-ation (Ipr) mutation have defects in the Fas antigen gene. The Ipr mice develop lymphadenopathy and suffer from a systemic lupus erythematosus-like autoimmune disease, indicating an important role for Fas antigen in the negative selection of autoreactive T cells in the thymus.

Only Abstract available here.

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Nature

356, 314 - 317

1992

http://www.nature.com/nature/journal/v356/n6367/abs/356314a0.html