WF10 (Immunokine, Macrokine)

WF10 is a powerful immunomodulator. WF10 is a chlorite-based drug that modulates macrophages functional states and can be safely administered to humans. WF10 potentially modulates disease-related up-regulation of immune responses both in vitro and in vivo. Thus immune response is influenced in a way that inappropriate inflammatory reactions are downregulated. (Schemppa, Reimb 2001)^[8.] Read more about WF10...

 

1. ​Harald Schemppa H, Manfred Reimb M, Dornisch K et al. Chlorite-Hemoprotein Interaction as Key Role for the Pharmacological Activity of the Chlorite-based Drug WF10. Arzneimittelforschung 2001; 51(7): 554-562 found at www.thieme-connect.com/ejournals/abstract/10.1055/s-0031-1300079

1. Drugs R D. 2004;5(4):242-4. Found at http://www.ncbi.nlm.nih.gov/pubmed/15230635
2. Schempp H, Reim M, Elstner EF. Chlorite-Hemoprotein Interaction as Key Role for the Pharmacological Activity of the Chlorite-based Drug WF10. Arzneimittelforschung 2001;51(7):554-62.
3. McGrath MS, Kahn JO, Herndier BG. Development of WF10, a novel macrophage regulating agent. Curr Opin Investig Drugs 2002 Mar;3(3):365-73
4. Nuvo Research Press Release November 8, 2010, found at http://www.news-medical.net/news/20101108/NUVO-announces-positive-results-from-WF10-Phase-2-clinical-trial-for-severe-allergic-rhinitis.aspx
5. Kuhne L, Konstandin M, Samstag Y, et al. WF10 Stimulates NK Cell Cytotoxicity by Increasing LFA-1-Mediated Adhesion to Tumor Cells Journal of Biomedicine and Biotechnology, vol. 2011, Article ID 436587, 6 pages, 2011. doi:10.1155/2011/436587 found at http://www.hindawi.com/journals/biomed/2011/436587/cta/
6. McGrath, Dr. M Interview via PRNewswire, Found at http://www.prnewswire.com/news-releases/oxo-chemie-presents-exciting-data-of-quantitatively-detectable-changes-of-gene-expression-pattern-in-macrophage-and-pbmcs-of-patients-treated-with-wf10-at-the-4th-international-workshop-on-hiv-cells-of-macrophage-lineage-and-ot-77481377.html
7. Press release via PRNewswire, found at http://www.prnewswire.com/news-releases/canadian-sites-approved-for-phase-3-clinical-trial-of-wf10-an-innovative-immune-approach-for-advanced-hiv-disease-73923957.html
8. Hanna L. WF10: A new, Immunomodulating Approach to HIV Treatment. Bulletin of experimental Treatment for AIDS, Summer 1999. Found at http://ww1.aegis.org/pubs/beta/1999/be990709.html
9. Extract found at http://www.als.net/forum/?g=posts&t=49246